ABCG1 Rabbit Polyclonal Antibody

CAT#: AP17071PU-N

ABCG1 rabbit polyclonal antibody, Purified



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CNY 6,314.00


货期*
4周

规格
    • 400 ul

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Specifications

Product Data
Applications FC, IHC, WB
Recommend Dilution Western blot: 1/1000.
Flow Cytometry: 1/10-1/50.
Immunohistochemistry: 1/10-1/50.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 366~395 from the Center region of Human ABCG1
Specificity This antibody detects ABCG1 at Center.
Formulation PBS with 0.09% (W/V) sodium azide
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Gene Name ATP binding cassette subfamily G member 1
Background ABCG1, one of five members of the ABCG subfamily, belongs to the large family of ATP-binding cassette (ABC) transporters. The protein is expressed in the plasma membrane of adipocytes, macrophages and other cell types. In these cells, ABCG1 facilitates cholesterol efflux to apoAI and/or high-density lipoprotein (HDL). The function of ABCG1 is linked to both obesity and atherosclerosis. First, studies in Abcg1 knockout mice showed that the gene deletion resulted in a significantly reduced size of fat cells. Second, the activation of ABCG1 expression promoted atherosclerotic lesion development while inactivation of macrophage ABCG1 expression reduced it in proatherogenic mice. In addition, ABCG1 plays a key role in lipoprotein formation by glia.
Synonyms ABC8, WHT1
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways ABC transporters
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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