CD130 (IL6ST) pTyr905 Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	Peptide ELISA: 1/1,000. Dot blot: 1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y905 of Human IL6ST
Specificity	This antiobdy reacts to Tyr905 phosphorylated CD130 / IL6ST.
Formulation	PBS State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 6 signal transducer
Database Link	Entrez Gene 3572 Human UniProt ID P40189
Background	IL6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.
Synonyms	Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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