Vitamin D Receptor (VDR) Rabbit Polyclonal Antibody
CAT#: AP20319PU-N
Vitamin D Receptor (VDR) rabbit polyclonal antibody, Aff - Purified
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CNY 1,999.00
CNY 4,640.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of VDR protein. |
Formulation | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15mM Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Predicted Protein Size | ~48.0 kDa |
Gene Name | vitamin D (1,25- dihydroxyvitamin D3) receptor |
Database Link | |
Background | The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally-specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9- cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcom,a melanom,a colon carcinoma and breast carcinoma cells. |
Synonyms | VDR, 1,25-dihydroxyvitamin D3 receptor |
Reference Data | |
Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
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