BubR1 (BUB1B) Rabbit Polyclonal Antibody

CAT#: AP20400PU-S

BubR1 (BUB1B) rabbit polyclonal antibody, Aff - Purified



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CNY 800.00


货期*
2周

规格
    • 25 ul

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Specifications

Product Data
Applications WB
Recommend Dilution Western blot: 1/500-1/1000.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of ubR1 protein.
(region surrounding Thr368)
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% sodium azide
Concentration 1.0 mg/ml
Purification Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 130 kDa
Gene Name BUB1 mitotic checkpoint serine/threonine kinase B
Background The N-end rule relates the in vivo half-life of a protein to the composition of its N-terminal residues. The N-end rule pathway is part of the ubiquitin system, which involves a three-step mechanism. Proteins targeted for degradation are bound on their N-terminal residue by Ubr1 (also designated E3 α and N-recognin), which catalyzes the covalent attachment of ubiquitin to the protein substrate. Two zinc finger domains and the RING-H2 finger domain of Ubr1 are essential for substrate recognition. Ubr1 is located on mouse chromosome 2 and on human chromosome 15 in the syntenic region. Ubr1 is a 220 kDa protein that is ubiquitously expressed in adult mouse, with the highest expression detected in skeletal muscle and heart. In mouse embryo, Ubr1 is primarily expressed in the branchial arches and in the tail and limb buds.
Synonyms Protein SSK1, BUBR1, MAD3L, BUB1 beta
Reference Data
Protein Families Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways Cell cycle
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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