HNRNPC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. Immunofluorescence: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of hn-RNP C1/C2 protein. (region surrounding Asp271)
Formulation	PBS, pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction > 95% (by SDS-PAGE) Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~33 kDa
Gene Name	heterogeneous nuclear ribonucleoprotein C (C1/C2)
Database Link	Entrez Gene 15381 MouseEntrez Gene 290046 RatEntrez Gene 3183 Human UniProt ID P07910
Background	The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP C1 and C2 are encoded by one gene; the two alternatively spliced transcript variants have been described.
Synonyms	Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1 / hnRNP C2, HNRPC
Reference Data
Protein Pathways	Spliceosome

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