Angiotensin Converting Enzyme 2 (ACE2) Rabbit Polyclonal Antibody
CAT#: AP20785PU-N
Angiotensin Converting Enzyme 2 (ACE2) rabbit polyclonal antibody, Aff - Purified
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CNY 4,640.00
货期*
2周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western blot: 1/500 - 1/1000. |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of ACE2 protein. (region surrounding Lys465) |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography (> 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~ 92 kDa |
Gene Name | angiotensin I converting enzyme 2 |
Database Link | |
Background | Angiotensin-converting enzyme (ACE) is a carboxylterminal dipeptidyl exopeptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/ electrolyte homeostasis. ACE2 is the first known human homolog of angiotensin- converting enzyme (ACE). Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells. |
Synonyms | Angiotensin-converting enzyme 2 |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Renin-angiotensin system |
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