GAD67 (GAD1) (526-537) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/8000. Immunohistochemistry on Paraffin Sections: 4 µg/ml. Western Blot: 0.3 - 1 µg/ml.
Reactivity	Bat, Bovine, Canine, Equine, Human, Mouse, Opossum, Porcine, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human GAD1 / GAD67 (NP_000808.2)
Specificity	This antibody detects GAD1 / GAD67 (Internal). It is expected to recognize isoform GAD67. There is no cross-reactivity expected with GAD2.
Formulation	Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	glutamate decarboxylase 1
Database Link	Entrez Gene 14415 MouseEntrez Gene 24379 RatEntrez Gene 2571 Human UniProt ID Q99259
Background	GAD1 / GAD67 is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome.
Synonyms	Glutamate decarboxylase 1, GAD-67
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus

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