GPR44 (PTGDR2) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	GPR44 antibody was raised against a 18 aa synthetic peptide near the amino terminus of human GPR44.
Specificity	This antibody reacts to G Protein-Coupled Receptor GPR44 (CRTH2).
Formulation	PBS containing 0.02% sodium azide. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	prostaglandin D2 receptor 2
Database Link	Entrez Gene 11251 Human UniProt ID Q9Y5Y4
Background	GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.
Synonyms	CRTH2, DL1R, PTGDR2, Prostaglandin D2 receptor 2
Reference Data

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