Nogo A (RTN4) (Isoform 1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23267PU-N

Nogo A (RTN4) (Isoform 1) (C-term) rabbit polyclonal antibody, Aff - Purified



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CNY 5,599.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IF, IHC, IP, WB
Recommend Dilution Western blot: At 1-2μg/ml with the appropriate system to detect Nogo-A in cells and tissues.
Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect Nogo-A in formalin fixed and paraffin embedded tissues. Boiling the sections is required.
Immunocytochemistry.
Immunprecipitation.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to the C-terminal of human Nogo-A
Specificity This antibody detects Reticulon-4 / RTN4 Isoform 1 at C-term. No cross reactivity with other proteins.
Formulation 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg Sodium Azide
State: Aff - Purified
State: Lyophilized Ig fraction
Reconstitution Method 0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name reticulon 4
Background Human neurite outgrowth inhibitor (NOGO) cDNAs encodes 3 splice variants: NOGOA, NOGOB and NOGOC. The longest cDNA, designated NOGOA, has an open reading frame of 1192 amino acids. It is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity. Nogo-A, a member of the Reticulon family, is expressed by oligodendrocytes and associates primarily with the endoplasmic reticulum. The acidic amino terminus of Nogo-A is detected at the cytosolic face of cellular membranes and may contribute to inhibition of axon regeneration at sites of oligodendrocyte injury. A multivalent form of the N terminus of Nogo-A affects the morphology of both neurons and other cell types.
Synonyms Foocen, Neurite outgrowth inhibitor, NOGO, Neuroendocrine-specific protein, NSP, Reticulon-5, KIAA0886
Reference Data
Protein Families Transmembrane
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