Myelin Basic Protein (MBP) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, IP, WB
Recommend Dilution	Western blot: At 1-2μg/ml with the appropriate system to detect MBP in cells and tissues. Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect MBP in formalin fixed and paraffin embedded tissues. Boiling the sections is required. Immunocytochemistry. Immunoprecipitation.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a sequence at the C-terminal of the human MBP
Specificity	This antibody detects Myelin Basic Protein at C-term. No cross reactivity with other proteins.
Formulation	50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	1.2% sodium acetate or neutral PBS.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	myelin basic protein
Database Link	Entrez Gene 17196 MouseEntrez Gene 24547 RatEntrez Gene 4155 Human UniProt ID P02686
Background	Myelin basic protein (MBP) is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. It is most abundant in hemopoietic system and contains seven exons distributed over 32-34 kb. MBP isolated from MS brain may differ in charge microheterogeneity which would affect antigenic determinants. MBP is mapped to chromosome 18q22-23. Failure in this gene expression would be correlated in the central white matter with extrapyramidal system degeneration signs. Moreover, it is a candidate autoantigen in the disease multiple sclerosis.
Synonyms	MBP
Reference Data

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