SNAP25 (C-term) Rabbit Polyclonal Antibody
CAT#: AP23410PU-N
SNAP25 (C-term) rabbit polyclonal antibody, Aff - Purified
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CNY 5,599.00
货期*
5周
规格
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western blot: 1 μg/ml. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide corresponding to a sequence at the C-terminal of human SNAP25 |
Specificity | This antibody detects SNAP25 (C-term). No cross reactivity with other proteins. |
Formulation | 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction |
Reconstitution Method | 0.2ml of distilled water will yield a concentration of 500μg/ml. |
Purification | Immunogen affinity purified |
Conjugation | Unconjugated |
Storage Condition | Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Gene Name | synaptosome associated protein 25kDa |
Database Link | |
Background | Synaptosome-associated protein of 25,000 daltons also known as SNAP-25 is a protein which in humans encodes a 25-kD protein of 206 amino acids. It was first investigated as a neuron-specific gene preferentially expressed in mouse hippocampus. The tSNARE (the target-membrane soluble NSFattachment protein receptor, where NSF is N-ethylmaleimide-sensitive fusion protein) synaptosomalassociated protein of 25 kDa (SNAP-25) is expressed in pancreatic B-cells and its cleavage by botulinum neurotoxin E (BoNT/E) abolishes stimulated secretion of insulin. In the nervous system, two SNAP-25 isoforms (a and b) have been described, which are produced by alternative splicing. Nagy et al. (2004) identified mammalian Snap25a and Snap25b as targets of protein kinase A, a key regulator of neurosecretion that primes slowly releasable pools and readily releasable pools of secretory vesicles. SNAP-25 inhibits P/Q-and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses. |
Synonyms | SNAP-25, SUP, SNAP, Super Protein, RIC4, ric-4 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | SNARE interactions in vesicular transport |
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