TLR7 (900-950) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Flow Cytometry. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 0.5 - 2 µg/ml.
Reactivity	Bovine, Canine, Equine, Human, Monkey, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide from a portion of amino acids 900-950 of Human TLR7
Specificity	This antibody reacts to Toll-like Receptor 7 (TLR7) at aa 900-950.
Formulation	PBS State: Purified State: Liquid purfied Ig fraction Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	toll like receptor 7
Database Link	Entrez Gene 170743 MouseEntrez Gene 317468 RatEntrez Gene 51284 Human UniProt ID Q9NYK1
Background	Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus. Activation of TLR7 by VSV results in stimulation of the immune response including IFNa secretion, suggesting the importance of TLR7 in virus recognition.
Synonyms	Toll-like receptor 7
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Toll-like receptor signaling pathway

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