TJP2 (411-467) Guinea Pig Polyclonal Antibody
CAT#: AP26409PU-N
TJP2 (411-467) guinea pig polyclonal antibody, Purified
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CNY 6,281.00
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Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Immunohistochemistry on Frozen Sections. Immunofluorescence. Western blot. The typical starting working dilution is 1/50. |
Reactivity | Human, Mouse |
Host | Guinea Pig |
Clonality | Polyclonal |
Immunogen | Amino acids 411-467 of Human ZO-2 |
Specificity | This antibody recognizes human zona occludens 2 (ZO-2). |
Formulation | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Purification | Protein A Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | tight junction protein 2 |
Database Link | |
Background | Zona occludens 2 (ZO-2) is an ~160 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain-containing proteins, like ZO-2, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and stability of the epithelial barrier depends on a complex of proteins composing different intercellular junctions, which include tight junctions, adherens junctions, and desmosomes. |
Synonyms | Tight junction protein 2, Tight junction protein ZO-2, ZO2, X104 |
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