Grin2b pSer1166 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/250.
Reactivity	Canine, Human, Mouse, Primate, Rat, Xenopus
Host	Rabbit
Clonality	Polyclonal
Immunogen	Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser 1166 of the NR2B subunit of the rat NMDA receptor
Specificity	Specific for the ~180k NMDAR NR2B subunit phosphorylated at Ser 1166 . Immunolabeling of the NMDA NR2B subunit band is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
Formulation	100 μl in 10 mM HEPES (pH 7.5), 150 mM Na Cl, 100 μg per ml BSA and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Purification	Affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	glutamate ionotropic receptor NMDA type subunit 2B
Database Link	Entrez Gene 24410 Rat UniProt ID Q00960
Background	The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell deat h (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). Overexpression of t he NR2B-subunit of the NM DA Receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a; Clayton et al., 2002b). Phosphorylation of Ser 1166 is thought to play an essential role in memory and neuronal development.
Synonyms	GRIN2B, NMDA Receptor 2B
Reference Data

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