Osteoprotegerin (TNFRSF11B) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA: 1 µg/ml. Western Blot: 0.2 µg/ml.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Purified recombinant Human Osteoprotegerin
Specificity	Recognizes Human Osteoprotegerin.  50 % cross-reactivity with mouse OPG: Other species not tested.
Formulation	PBS, pH 7.4 State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore in aqua bidest to 1 mg/ml
Purification	Affinity Chromatography using Human OPG
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily member 11b
Database Link	Entrez Gene 4982 Human UniProt ID O00300
Background	Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.
Synonyms	OPG, OCIF
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction

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