Osteoprotegerin (TNFRSF11B) Goat Polyclonal Antibody

CAT#: AP31589PU-N

Osteoprotegerin (TNFRSF11B) goat polyclonal antibody, Aff - Purified

Size: 10 ug 100 ug



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CNY 23,177.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications ELISA, WB
Recommend Dilution ELISA: 1 µg/ml.
Western Blot: 0.2 µg/ml.
Reactivity Human
Host Goat
Clonality Polyclonal
Immunogen Purified recombinant Human Osteoprotegerin
Specificity Recognizes Human Osteoprotegerin. 
50 % cross-reactivity with mouse OPG:
Other species not tested.
Formulation PBS, pH 7.4
State: Aff - Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore in aqua bidest to 1 mg/ml
Purification Affinity Chromatography using Human OPG
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Gene Name tumor necrosis factor receptor superfamily member 11b
Background Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.
Synonyms OPG, OCIF
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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