KCNC3 (317-328) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/16000 (Detection Limit). Western Blot: 0.3-1 µg/ml. Approx 80kDa band observed in Mouse and Rat Brain lysates.
Reactivity	Human, Mouse, Porcine, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_004968.2.
Specificity	Recognizes KCNC3 / Kv3.3 (317-328).
Formulation	Tris saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	potassium voltage-gated channel subfamily C member 3
Database Link	Entrez Gene 3748 Human UniProt ID Q14003
Background	KCNC3 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Synonyms	Potassium voltage-gated channel subfamily C member 3, Voltage-gated potassium channel subunit Kv3.3, KSHIIID
Note	Calculated Molecular Weight: 81.9kDa (Mouse NP_032448.2).
Reference Data

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