GAD67 (GAD1) Chicken Polyclonal Antibody
CAT#: AP31805PU-N
GAD67 (GAD1) chicken polyclonal antibody, Aff - Purified
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CNY 7,688.00
货期*
5周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Western Blot. Immunocytochemistry. Immunohistochemistry. Recommended Dilutions: 1/2000-1/5000 for Western blots. 1/1000-1/2000 for Immunohistochemistry and Immunocytochemistry using 2% paraformaldehyde-fixed tissues or cells. Quality Control: This antibody was analyzed by Immunohistochemistry (at a concentration of 1 µg/ml) using Fluorescein-labeled Goat anti-Chicken IgY (1/500 dilution, Cat.-No AP31795FC-N) as the secondary reagent. |
Reactivity | Human, Mouse, Rat |
Host | Chicken |
Clonality | Polyclonal |
Immunogen | Synthetic peptide KLH conjugated corresponding to a region near the C-terminus of this gene product, and was 100% conserved between the Human (Q99259), Mouse (P48318) and Rat (NP_058703) gene products. After repeated injections into the hens, immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity purified using a peptide column. |
Specificity | Recognizes Glutamic Acid Decarboxylase (GAD1/GAD67). |
Formulation | 10mM PBS (0.9%, w/v), pH 7.2 containing 0.02% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified (0.45 µm filter sterilized) IgY fraction. |
Concentration | lot specific |
Purification | Affinity Chromatography using a peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted in the dark at 2-8°C. |
Gene Name | glutamate decarboxylase 1 |
Database Link | |
Background | Human Glutamic Acid Decarboxylase (GAD-67), [EC 4.1.1.15] is a 66,987 dalton protein (594 amino acids) selectively expressed in a subpopulation of GABAergic neurons of the CNS. It catalyzes the decarboxylation of glutamic acid, forming the inhibitory neurotransmitter β-amino butyric acid (GABA). It is also know as GAD-1. |
Synonyms | Glutamate decarboxylase 1, GAD-67 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Human iPSC Modeling of Genetic Febrile Seizure Reveals Aberrant Molecular and Physiological Features Underlying an Impaired Neuronal Activity
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Biomedicines
,PubMed ID 35625812
[GAD1]
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