H2A.Z (H2AFZ) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/100-1/5000. Immunohistochemistry: 1/100-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from internal part of Human Histone H2A.Z.
Specificity	This antibody reacts with H2A/z.
Formulation	0.1M Tris, 0.1M Glycine, 2% Sucrose State: Purified State: Lyophilized powder Preservative: None
Reconstitution Method	Restore in distilled water
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibody at 2-4°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	H2A histone family member Z
Database Link	Entrez Gene 3015 Human UniProt ID P0C0S5
Background	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Histone H2A.Z is a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
Synonyms	H2AFZ, H2AZ, H2A/z
Reference Data

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