CD309 / VEGFR-2 / Flk-1 Rabbit Polyclonal Antibody

CAT#: AP33406PU-N

CD309 / VEGFR-2 / Flk-1 rabbit polyclonal antibody, Purified



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CNY 3,450.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications FC, WB
Recommend Dilution Western blot: 1-5 µg/ml.
FACS: 1-5 µg/ml.
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure recombinant Mouse soluble endogenous Flk-1 (Ala20 – Pro673) (Cat.-No AP26035PU-N).
Specificity This antibody detects endogenous Mouse sVEGFR-2/Flk-1. Other species not tested.
Formulation PBS, pH 7.2
State: Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore in sterile water to a concentration of 0.1-1.0 mg/ml. Centrifuge vial prior to opening.
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Background Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have been identified, an endogenous selective inhibitor of lymphatic vessel growth has not to our knowledge been previously described. A splice variant of the gene encoding vascular endothelial growth factor receptor-2 (VEGFR-2) that encodes a secreted form of the protein, designated endogenous soluble VEGFR-2 (esVEGFR-2/KDR) has been described. The endogenous soluble esKDR inhibits developmental and reparative lymphangiogenesis by blocking VEGF-C function. Tissue-specific loss of esKDR in mice induced, at birth, spontaneous lymphatic invasion of the normally alymphatic cornea and hyperplasia of skin lymphatics without affecting blood vasculature. Administration of esKDR inhibited lymphangiogenesis but not hemangiogenesis induced by corneal suture injury or transplantation, enhanced corneal allograft survival and suppressed lymphangioma cellular proliferation. Naturally occurring esKDR thus acts as a molecular uncoupler of blood and lymphatic vessels; modulation of esKDR might have therapeutic effects in treating lymphatic vascular malformations, transplantation rejection and, potentially, tumor lymphangiogenesis and lymphedema.
Synonyms VEGFR2, FLK1, KDR, VEGF Receptor 2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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