Deformed Epidermal Autoregulatory Factor 1 (DEAF1) (C-term) Rabbit Polyclonal Antibody
CAT#: AP51228PU-N
Deformed Epidermal Autoregulatory Factor 1 (DEAF1) (C-term) rabbit polyclonal antibody, Aff - Purified
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CNY 6,160.00
货期*
5周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | ELISA: 1/1000. Western Blot: 1/100-1/500. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 473-502 amino acids from the C-terminal region of human DEAF1 |
Specificity | This antibody recognizes Human DEAF1 (C-term). |
Formulation | PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | DEAF1, transcription factor |
Database Link | |
Background | Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. |
Synonyms | SPN, ZMYND5, Suppressin, SPN, NUDR |
Note | Molecular Weight: 59327 Da |
Reference Data | |
Protein Families | Secreted Protein, Transcription Factors, Transmembrane |
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