DIAPH3 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 1060-1090 amino acids from the C-terminal region of human DIAPH3.
Specificity	This antibody recognizes Human DIAPH3 (C-term).
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	diaphanous related formin 3
Database Link	Entrez Gene 81624 Human UniProt ID Q9NSV4
Background	DIAPH3 binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).
Synonyms	DIAP3, Diaphanous homolog 3, Diaphanous-3, DRF3
Note	Molecular Weight: 136926 Da
Reference Data
Protein Pathways	Regulation of actin cytoskeleton

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