IL12RB2 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	This antibody is suitable for flow cytometry, immunohistochemistry on paraffin sections and Western blotting. The suggested dilution is: Flow cytometry: 1/10-1/50. Immunohistochemistry on paraffin sections: 1/50-1/100. Western blotting: 1/100-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
Specificity	This antibody detects human IL12RB2 at C-term.
Formulation	PBS with 0.09% (W/V) Sodium Azide. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a protein A column; followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 12 receptor subunit beta 2
Database Link	Entrez Gene 3595 Human UniProt ID Q99665
Background	The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Synonyms	IL-12 receptor beta-2, IL-12R-beta-2
Note	Molecular Weight: 97135 Da
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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