Melanophilin (MLPH) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin sections: 1/10-1/50. Western blot: 1/100-1/500. Enzyme immunoassay: 1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 540-569aa) of human Melanophilin.
Specificity	This antibody recognizes Melanophilin / MLPH at C-term.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	melanophilin
Database Link	Entrez Gene 79083 Human UniProt ID Q9BV36
Background	The MLPH gene encodes a member of the exophilin subfamily of Rab effector proteins, Melanophilin. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Synonyms	Mlph, Ln, Slac2a, Exophilin-3, Leaden protein, Synaptotagmin-like protein 2a
Note	Molecular Weight: 65949 Da
Reference Data

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