DERL1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA.  Western Blot: 1/200-1/2000. Immunohistochemistry: 1/50-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from C-terminal domain of Derlin-1 protein
Specificity	This antibody reacts with 28 kDa Derlin-1.
Formulation	0.1M Tris, 0.1M Glycine, 2% Sucrose State: Serum State: Lyophilized serum Preservative: None
Reconstitution Method	Restore in 0.2 ml distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store the reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	derlin 1
Database Link	Entrez Gene 79139 Human UniProt ID Q9BUN8
Background	DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Synonyms	Der1-like protein 1, DERL1, DER1, DERtrin-1
Reference Data

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