Neisseria gonorrhoeae Mouse Monoclonal Antibody [Clone ID: 801]

Specifications

Product Data
Clone Name	801
Applications	IA
Recommend Dilution	May be used in immunoassays to detect and quantitate N. gonorrhoeae. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Reactivity	Neisseria gonorrhoeae
Host	Mouse
Clonality	Monoclonal
Immunogen	Pool of UV-inactivated N. gonorrhoeae cells. Neisseria Reference Laboratory strains G-7, R-11 and 71222 (W-I), 5766 and 8038 (W-II), 8660 (W-III).
Specificity	This antibody does not cross-react with: N. meningitidis, N. cinerea, N. lactamica, M. sicca, B. catarrhalis, E. coli, P. mirabilis, Gardnerella vaginalis, Group B. Strep. or Chlamydia.
Formulation	PBS buffer, pH 7.4, without preservatives. State: Azide Free State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Neisseria gonorrhoeae infections are acquired by sexual contact and usually affect the mucous membranes of the urethra in males and the endocervix and urethra in females, although the infection may disseminate to a variety of tissues. The pathogenic mechanism involves the attachment of the bacterium to nonciliated epithelial cells via pili (fimbriae) and the production of lipopolysaccharide endotoxin. Similarly, the lipopolysaccharide of Neisseria meningitidis is highly toxic, as it has an additional virulence factor in the form of its antiphagocytic capsule. Both pathogens produce IgA proteases which promote virulence. Many normal individuals may harbor Neisseria meningitidis in the upper respiratory tract, but Neisseria gonorrhoeae is never part of the normal flora and is only found after sexual contact with an infected person (or direct contact, in the case of infections in the newborn).
Reference Data

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