HIV-2 gp36 Mouse Monoclonal Antibody [Clone ID: BDI411]

Specifications

Product Data
Clone Name	BDI411
Applications	ELISA, IP, WB
Recommend Dilution	Suitable for use in Western blot (1/1,000), ELISA (1/500) and Immunoprecipitation.
Reactivity	Human Immunodeficiency Virus 2
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant gp36, amino acids 390-702 (Art. No. BIN07...)
Specificity	This antibody is specific for HIV-2 gp36 antigen.
Formulation	1X PBS, pH 7.2 containing 0.01% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	HIV2 infections at present, are predominantly found in west Africa where it is the dominant form of HIV. Both HIV1 and HIV2 have the same modes of transmission and are associated with similar opportunistic infections and AIDS. In persons infected with HIV2, immunodeficiency seems to develop more slowly and to be milder, but as the disease advances, HIV2 infectiousness seems to increase. Little is known about the best approach to the clinical treatment and care of patients infected with HIV2. Some drugs used to treat HIV1 are ineffective. HIV1 and HIV2 have similar gag (viral core) and pol (polymerase) regions, they have relatively dissimilar env (envelope) regions. Owing to this lack of homology in the envelope region, there is little serologic cross-reactivity of the antibodies directed against the envelope antigens of both HIV1 and HIV2. The env gp36 ectodomain is highly conserved and elicits a type-specific antibody response. Hence, most licensed diagnostic assays incorporate gp36-derived antigens to detect HIV2 specific antibodies. It is becoming important to differentiate between single infection with either HIV1 or HIV2 and dual infection.
Synonyms	HIV2, Human immunodeficiency virus type 2
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.