Desmin Mouse Monoclonal Antibody [Clone ID: RD301]
CAT#: BM6010P
Desmin mouse monoclonal antibody, clone RD301, Purified
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CNY 5,186.00
货期*
5周
规格
Cited in 2 publications. |
Specifications
Product Data | |
Clone Name | RD301 |
Applications | IF, IHC, WB |
Recommend Dilution | Western blot. Immunohistochemistry on Frozen sections. Immunocytochemistry. Recommended Dilutions: 1/100-1/200 for Immunohistochemistry with Avidin-Biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1/100-1/1000 for Immunoblotting applications. |
Reactivity | Canine, Chicken, Hamster, Human, Mouse, Porcine, Rabbit, Rat, Zebrafish |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Cytoskeletal desmin extract of chicken gizzard |
Specificity | RD301 reacts exclusively with Desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma. |
Formulation | PBS with 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freeze-thaw cycles. |
Database Link | |
Background | Desmin (53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed. |
Synonyms | DES |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
---|
Cardiac fibroma: A Clinicopathologic Study of a Series of 12 Cases
,null,
Cardiovascular Pathology
,PubMed ID 34433104
[DES]
|
Clinicopathological and immunohistochemical features of pulmonary artery sarcoma: A report of three cases and review of the literature
,null,
Oncology Letters
,PubMed ID 27073558
[DES]
|
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