Cytokeratin 14 (KRT14) Guinea Pig Polyclonal Antibody
CAT#: BP5009
Cytokeratin 14 (KRT14) guinea pig polyclonal antibody, Serum
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CNY 6,094.00
货期*
5周
规格
Cited in 6 publications. |
Product images
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | Western Blot: 1/5000-1/10000. Cytological Material. Immunohistochemistry on Frozen Sections: 1/100-1/200. Immunohistochemistry on Paraffin Sections: 1/50 (microwave treatment recommended). Incubation Time: 1 h at RT, extended with Paraffin. |
Reactivity | Bovine, Human, Mouse |
Host | Guinea Pig |
Clonality | Polyclonal |
Immunogen | Peptide against Human K14 C-VSTHEQVLRTKN (460-472) |
Specificity | The antiserum reacts with keratin K14, expressed in the basal cells of the larynx, esophagus, trachea, bladder, prostate, cervix, vagina, breast acini, skin and sweat glands. In several studies the correlation between the expression of keratin K14 in different types of carcinomas (putatively derived from basal epithelial cells) and prognosis has been discussed (see references listed below). Reactive Polypeptide: Acidic keratin K14 (Mr 50 000; formerly also designated cytokeratin 14), expressed in basal and first suprabasal layers of epidermis. Tested cultured cell lines: BPH-1 (derived from non-neoplastic prostatic tissue). |
Formulation | State: Serum State: Liquid stabilized antiserum Stabilizer: 0.5% BSA Preservative: 0.09% Sodium Azide |
Conjugation | Unconjugated |
Storage Condition | Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles. |
Gene Name | keratin 14 |
Database Link | |
Background | Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The α-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and in addition they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility. Acidic keratin K14 (Mr 50 000; formerly also designated cytokeratin 14), expressed in basal and first suprabasal layers of epidermis. |
Synonyms | Cytokeratin-14, CK14, Keratin 14, K14, KRT14 |
Reference Data |
Citations (6)
The use of this Antibodies has been cited in the following citations: |
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AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis.
,null,
eLife
,PubMed ID 37017303
[KRT14]
|
Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis
,null,
Nature Communications
,PubMed ID 36631478
[KRT14]
|
ID1 and CEBPA coordinate epidermal progenitor cell differentiation
,null,
Development (Cambridge, England)
,PubMed ID 36330928
[KRT14]
|
Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1
,Lough, KJ;Spitzer, DC;Bergman, AJ;Wu, JJ;Byrd, KM;Williams, SE;,
Development
,PubMed ID 32554531
[KRT14]
|
Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers
,Ying, Z;Beronja, S;,
Cell Stem Cell
,PubMed ID 32059806
[KRT14]
|
Closing the Gap: Mouse Models to Study Adhesion in Secondary Palatogenesis
,Lough, KJ;Byrd, KM;Spitzer, DC;Williams, SE;,
J. Dent. Res.
,PubMed ID 28817360
[KRT14]
|
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