STAT4 Mouse Monoclonal Antibody [Clone ID: OTI2A2]

Specifications

Product Data
Clone Name	OTI2A2
Applications	IHC, WB
Recommend Dilution	WB: 1:100, IHC 1:50
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant fragment expressed in E.coli corresponding to amino acids 633-652 of human Stat4
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	85.8 kDa
Gene Name	signal transducer and activator of transcription 4
Database Link	NP_003142 Entrez Gene 20849 MouseEntrez Gene 367264 RatEntrez Gene 6775 Human UniProt ID Q14765
Background	Stat4 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
Synonyms	SLEB11
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Jak-STAT signaling pathway

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