FOXA2 Mouse Monoclonal Antibody [Clone ID: OTI3C10]

Specifications

Product Data
Clone Name	OTI3C10
Applications	FC, IF, IHC, WB
Recommend Dilution	WB: 1:1000; IHC: 1:50; IF: 1:50-1:100; Flow 1:1,000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein expressed in E.coli corresponding to amino acids 300-458 of human FOXA2
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	48.1 kDa
Gene Name	forkhead box A2
Database Link	NP_710141 Entrez Gene 15376 MouseEntrez Gene 25099 RatEntrez Gene 3170 Human UniProt ID Q9Y261
Background	FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene
Synonyms	HNF3B; TCF3B
Reference Data
Protein Families	Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
Protein Pathways	Maturity onset diabetes of the young

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