STK39 Mouse Monoclonal Antibody [Clone ID: OTI2E10]

Specifications

Product Data
Clone Name	OTI2E10
Applications	IHC, WB
Recommend Dilution	WB 1:2000 IHC 1:50
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human STK39 expression vector
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	59.6 kDa
Gene Name	serine/threonine kinase 39
Database Link	NP_037365 Entrez Gene 53416 MouseEntrez Gene 54348 RatEntrez Gene 27347 Human UniProt ID Q9UEW8
Background	This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
Synonyms	DCHT; PASK; SPAK
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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