KDM4C Mouse Monoclonal Antibody [Clone ID: OTI8A1]

Specifications

Product Data
Clone Name	OTI8A1
Applications	IHC, WB
Recommend Dilution	WB 1:500, IHC 1:50
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human KDM4C expression vector
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	120.0 kDa
Gene Name	lysine demethylase 4C
Database Link	NP_055876 Entrez Gene 23081 Human UniProt ID Q9H3R0
Background	This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
Synonyms	GASC1; JHDM3C; JMJD2C; TDRD14C
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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