ROR alpha (RORA) Mouse Monoclonal Antibody [Clone ID: OTI2E8]

Specifications

Product Data
Clone Name	OTI2E8
Applications	WB
Recommend Dilution	WB 1:500
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 98-345 of human RORA (NP_002934) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	62.1 kDa
Gene Name	RAR related orphan receptor A
Database Link	NP_002934 Entrez Gene 19883 MouseEntrez Gene 300807 RatEntrez Gene 6095 Human UniProt ID P35398
Background	The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Synonyms	NR1F1; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

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