CD40 Mouse Monoclonal Antibody [Clone ID: MAB89]

Specifications

Product Data
Clone Name	MAB89
Applications	FC, FN, IHC
Recommend Dilution	Cell activation, FACS surface, ImmunoHistoChemistry frozen sections, ImmunoHistoChemistry paraffin sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	anti-μ activated tonsillar human B cells
Specificity	human CD40
Formulation	Purified: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8 Coupled: 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol State: Purified
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	CD40 molecule
Database Link	Entrez Gene 958 Human UniProt ID P25942
Background	CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin. (Vallé A. et al, 1989; Eur. J. Immunol., 19: 1463-1469; O’ Sullivan B. et al, 2003; Crit. Rev. Immunol., 23: 83-107)
Synonyms	TNFRSF5, CDw40, Bp50
Reference Data

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