LOC102723996 Mouse Monoclonal Antibody [Clone ID: GM13C1]

Specifications

Product Data
Clone Name	GM13C1
Applications	ELISA, FC, WB
Recommend Dilution	Flow Cytometry: 1.2 µg/106 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Genetic immunisation with cDNA encoding Human ICOSL (Extracellular Domain).
Specificity	This antibody recognizes Human CD275 / ICOS Ligand. Other species not tested.
Formulation	Phosphate buffered saline, pH 7.2 State: Purified State: Liquid purified Ig fraction from Cell Culture Supernatant
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ICOS ligand
Database Link	Entrez Gene 102723996 Human UniProt ID O75144
Background	Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS)(1). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secre-tion (2,3).
Synonyms	B7 homolog 2, B7-like protein Gl50, B7-related protein 1, ICOSLG, B7H2, B7RP1, B7RP-1, ICOSL, KIAA0653
Reference Data

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