Cytokeratin 17 (KRT17) Mouse Monoclonal Antibody [Clone ID: Ks17.E3]

Specifications

Product Data
Clone Name	Ks17.E3
Applications	FC, IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/100-1/1000. Immunocytochemistry. Immunohistochemistry on Frozen and Paraffin Embedded tissues: 1/25-1/200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complec (ABC) as detection regant. Flow Cytometry: 1/25-1/200.
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	A cytoskeletal preparation from Rat colon.
Specificity	Clone E3 reacts with Cytokeratin 17 in basal layers of pseudo-stratified and transitional epithelia.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	46 kDa
Gene Name	keratin 17
Database Link	Entrez Gene 3872 Human UniProt ID Q04695
Background	Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immuno-histochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Synonyms	Cytokeratin-17, Keratin-17, Keratin 17, KRT17, CK17, K17
Reference Data

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