Insulin (INS) Mouse Monoclonal Antibody [Clone ID: K36aC10]

Specifications

Product Data
Clone Name	K36aC10
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin/Paraffin Sections: Use a dilution of 1/25-1/50 in an ABC method (30 minutes at room temperature). Recommended Positive Control: Pancreas.
Reactivity	Bovine, Canine, Equine, Feline, Guinea Pig, Human, Porcine, Rabbit, Rat, Sheep
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Insulin.
Specificity	This antibody recognizes purified Insulin from the pancreas of Human, Bovine, Horse, Sheep as well as Proinsulin from Human. Cross reaction has been observed with insulin containing cells in fixed sections of pancreas from Human, Porcine, Dog, Rabbit, Bovine, Sheep, Rat, Guinea Pig and Cat. Cellular Localization: Cytoplasmic.
Formulation	State: Ascites State: Diluted Ascites Preservative: < 0.1% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	insulin
Database Link	Entrez Gene 3630 Human UniProt ID P01308
Background	Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
Synonyms	INS
Reference Data

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