CD34 Mouse Monoclonal Antibody [Clone ID: 34C02]

Specifications

Product Data
Clone Name	34C02
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistology on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human CD34 protein.
Specificity	This antibody reacts with CD34 - expressed on lymphoid and myeloid hematopoietic progenitor cells. Also reacts with vascular endothelial cells in normal tissues and in benign and malignant proliferations.
Formulation	10 mM PBS, pH 7.4 without preservatives or stabilizers State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore in sterile Water to a concentration of 1.0 mg/ml.
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	CD34 molecule
Database Link	Entrez Gene 947 Human UniProt ID P28906
Background	The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid and myeloid hematopoietic progenitor cells.
Synonyms	Hematopoietic progenitor cell marker
Reference Data

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