Eng Rabbit Polyclonal Antibody

CAT#: DP3518

Eng rabbit polyclonal antibody, Purified

Size: 100 ug 200 ug



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CNY 4,320.00


货期*
5周

规格
    • 200 ug

Product images

Specifications

Product Data
Applications ELISA, FC, WB
Recommend Dilution ELISA (1-15 µg/ml).
Western blot (1-5 µg/ml).
Flow Cytometry (1-20 µg/ml).
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure recombinant Mouse soluble CD105 produced in Insect cells.
The recombinant soluble CD105 consists of amino acid 26(Glu) to 581 (Gly) and is fused to a C-terminal His-tag (6xHis).
Specificity This antibody detects Mouse CD105/Endoglin. Other species not tested.
Formulation PBS, pH 7.2 without preservatives
State: Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore with sterile water to a concentration of 0.1-1.0 mg/ml
Purification Protein A Chromatography (+his tag depleted)
Conjugation Unconjugated
Storage Condition

Prior to reconstitution store at 2-8°C.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name endoglin
Background Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart evelopment. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular isorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.
Synonyms ENG, END, HHT1, ORW, ORW1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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