NFKB1 Rabbit Polyclonal Antibody
CNY 8,025.00
货期*
4周
规格
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Specifications
Product Data | |
Applications | ELISA, IP, WB |
Recommend Dilution | Immunoprecipitation,. Western Blot: 1/1000. ELISA. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Human NFkB p105 peptide corresponding to a region near the N-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH) |
Specificity | This antibody is corresponding to a region near the N-terminus of the Human protein conjugated to Keyhole Limpet Hemocyanin (KLH). |
Formulation | State: Serum State: Liquid serum containing 0.01% (w/v) Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
Gene Name | nuclear factor kappa B subunit 1 |
Database Link | |
Background | NFkB is a transcription regulator that is activated by various intra and extra cellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of homo and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Serine 529 is located in a negatively charged region (amino acids 422-540) that is phosphorylated in response to phorbol myristate acetate plus calcium ionophore activation. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. |
Synonyms | NFKB1, KBF1, EBP-1, EBP1, NF-kappa-B p50 |
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