Msr1 Rat Monoclonal Antibody [Clone ID: 2F8]

Specifications

Product Data
Clone Name	2F8
Applications	ELISA, FC, FN, IHC, IP, WB
Recommend Dilution	ELISA. Western blot: Recognises CD204 in J774 cells under Non-Reduced Conditions only. Functional assays. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Flow cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 10e6 cells in 100 µl.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	RAW264 cell line.
Specificity	This antibody recognises the Murine Scavenger Receptor Class A (SRA), type I and II, also known as CD204.
Formulation	PBS, pH 7.4 without preservatives State: Low Endotoxin State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	macrophage scavenger receptor 1
Database Link	Entrez Gene 20288 Mouse UniProt ID P30204
Background	CD204 is expressed by tissue macrophages and functions both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages binding to ligand rich tissues e.g. atherosclerotic lesions. Clone 2F8 inhibits the uptake of acetylated low-density lipoproteins and also inhibits divalent cation independent adhesion.
Synonyms	MSR1, SCARA1
Note	Endotoxin Level: less than 0.01 EU/µg. Recent research shows that clone 2F8 recognises an epitope within SRA that is polymorphic in the SRA from C57BL/6 mice. Clone 2F8 is therefore unsuitable for use with the C57BL/6 mouse strain.
Reference Data

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