EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: C595]

CAT#: SM1708

EMA (MUC1) mouse monoclonal antibody, clone C595, Purified



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CNY 7,538.00


货期*
4周

规格
    • 200 ug

Product images

Specifications

Product Data
Clone Name C595
Applications ELISA, FC, IF, IHC, WB
Recommend Dilution Western Blot.
Flow Cytometry.
ELISA: 1/100-1/1000.
Immunofluorescence.
Immunohistochemistry on Frozen and Paraffin Sections: This product does not require protein digestion pre-treatment of paraffin sections but does requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Recommended Positive Control: Breast carcinoma.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Urinary MUC-1 mucin. Spleen cells from immunised Balb/c mice were fused with cells of a mouse myeloma cell line.
Specificity This antibody recognises CD227, the breast cancer associated mucin encoded by the Muc-1 gene. In normal tissues expression is restricted to specialised glandular epithelial.
SM1708 recognizes the peptide epitope ARG-PRO-ALA-PRO within the protein core of the Mucin.
Formulation PBS containing 0.09% Sodium Azide as preservative.
State: Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Affinity Chromatography on Protein G.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name mucin 1, cell surface associated
Background MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
Synonyms MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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