c Kit (KIT) Mouse Monoclonal Antibody [Clone ID: 104D2]

Specifications

Product Data
Clone Name	104D2
Applications	FC
Recommend Dilution	Indirect immunofluorescence analysis by Flow cytometry.
Reactivity	Bovine, Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	MOLM-1 megakaryocytic cells
Specificity	This antibody detects extracellular part of CD117 / c-Kit protooncogen.
Formulation	Phosphate buffered saline (PBS) Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4 Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	KIT proto-oncogene receptor tyrosine kinase
Database Link	Entrez Gene 3815 Human UniProt ID P10721
Background	CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.
Synonyms	SCFR, KIT
Reference Data

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