FeLV envelope glycoprotein SU gp70 Mouse Monoclonal Antibody [Clone ID: C11D8]

Specifications

Product Data
Clone Name	C11D8
Applications	FC, IHC, IP, WB
Recommend Dilution	Flow Cytometry. Western Blot. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections. Neutralization. Notes: Removal of the preservative is recommended prior to use in functional assays. Recommended Dilutions: Western Blot 1/100-1/2000, Immunohistochemistry-Paraffin 1/10-1/500, Immunoprecipitation 1/10-1/500, Flow Cytometry 1/10-1/1000, Immunohistochemistry-Frozen 1/10-1/500, Immunohistochemistry 1/10-1/500.
Reactivity	Feline Leukemia Virus
Host	Mouse
Clonality	Monoclonal
Immunogen	Made to Viral FELINE LEUKAEMIA VIRUS gp70
Specificity	This antibody recognizes the gp85/gp70 envelope glycoprotein of leukaemia virus. The antibody specifically recognises the epitope defined by amino acids 214-218 of the gp70 sequence (aa MGPNL). Some weak cross-reactivity with the sequence MGPLL found in the FeLV p15e membrane protein may also occur. This antibody effectively neutralizes all three FeLV subgroups (A,B and C).
Formulation	PBS, pH 7.2 containing 0.05% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction from Tissue Culture Supernatant
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P06752
Background	FeLV is a retrovirus (family Oncovirinae) that can cause severe immunosuppression, severe non regenerative anemia, and a variety of neoplasms. The 3 main subtypes (FeLVA, FeLVB and FeLVC) may act independently or together to cause a variety of diseases. The major envelope glycoprotein (gp70) is used to bind to target cells and varies with the FeLV subtype.
Synonyms	Feline leukemia virus env, gp70, p15E
Reference Data

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