CD177 Mouse Monoclonal Antibody [Clone ID: MEM-166]

Specifications

Product Data
Clone Name	MEM-166
Applications	FC
Recommend Dilution	Flow cytometry (use 10 µl of neat - 1/10 diluted antibody to label 10e6 cells in 100 µl).
Reactivity	Human, Monkey, Rhesus Monkey
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognises human CD177 (neutrophil glycoprotein NB1). The neutrophil NB1 antigen is expressed by 97% of the caucasian population. Antibodies against NB1 can be involved in neonatal alloimmune neutropenia (NAN). Antibody reactivity and working conditions may vary between species.
Formulation	PBS with 0.09% sodium azide as preservative and 1% BSA as stabelizer Label: FITC State: Liquid, purified immunoglobulin fraction Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Protein G affinity chromatography
Conjugation	FITC
Storage Condition	Store the antibody at 4°C for one month or at -20°C for longer. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	CD177 molecule
Database Link	Entrez Gene 57126 Human UniProt ID Q8N6Q3
Background	Cd177 (NP1), a glycosyl phosphatidylinositol (GPI) linked N glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia and analyses showed cell surface expression of a 60 kDa protein, 14 kDa greater than the predicted size, probably due to the presence of 3 potential N glycosylation sites. Immunohistochemistry demonstrated expression in bone marrow early erythroblasts, megakaryocytes, promyelocytes, and myelocytes. The neutrophil NB1 antigen (CD177) is expressed by 97% of the caucasian population. Antibodies against NB1 can be involved in neonatal alloimmune neutropenia (NAN).
Synonyms	NB1, PRV1, HNA-2a, HNA2a
Reference Data

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