HLA Class I ABC Xenograft marker Rat Monoclonal Antibody [Clone ID: YTH862.2]
CAT#: SM2012P
HLA Class I ABC Xenograft marker rat monoclonal antibody, clone YTH862.2, Purified
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CNY 6,116.00
货期*
5周
规格
Cited in 2 publications. |
Specifications
Product Data | |
Clone Name | YTH862.2 |
Applications | FC, FN, IF, IHC, IP |
Recommend Dilution | Immunoprecipitation. Immunofluorescence. Functional Assays: Removal of Sodium Azide by dialysis is recommended prior to use. Immunohistochemistry on Frozen Sections. Flow Cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 106 cells in 100 µl. |
Reactivity | Human |
Host | Rat |
Clonality | Monoclonal |
Immunogen | PHA activated Human peripheral blood lymphocytes. Spleen cells from immunised DA rats were fused with cells of the rat Y3 myeloma cell line. |
Specificity | This antibody recognizes a monomorphic determinant on the Human HLA Class I heavy chain. Epitope analysis has shown that this antibody binds in the alpha-1 domain. Antibody SM2012P detects the Human HLA class I ABC antigen without cross-reactivity to Mouse. Studies have shown that this antibody may be able to induce apoptosis in activated but not resting T cells (See Genestier, L. et al. for details). Negative Species: Mouse. |
Formulation | PBS State: Purified State: Liquid purified IgG fraction from Tissue Culture Supernatant Preservative: 0.09% Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein G |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Background | The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. These proteins are found on the surface of almost all nucleated somatic cells. |
Synonyms | MHC class I ABC, HLA Class 2 ABC |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy
,Delgado-Tirado, S;Amarnani, D;Zhao, G;Rossin, EJ;Eliott, D;Miller, JB;Greene, WA;Ramos, L;Arevalo-Alquichire, S;Leyton-Cifuentes, D;Gonzalez-Buendia, L;Isaacs-Bernal, D;Whitmore, HAB;Chmielewska, N;Duffy, BV;Kim, E;Wang, HC;Ruiz-Moreno, JM;Kim, LA;Arboleda-Velasquez, JF;,
Scientific reports
,PubMed ID 33257736
[HLA Class I]
|
Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites
,null,
Oncotarget
,PubMed ID 26934555
|
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