CD14 Mouse Monoclonal Antibody [Clone ID: MEM-18]
CAT#: SM3009B
CD14 mouse monoclonal antibody, clone MEM-18, Biotin
Conjugation: Unconjugated FITC
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CNY 3,810.00
Cited in 9 publications. |
Specifications
Product Data | |
Clone Name | MEM-18 |
Applications | FC, WB |
Recommend Dilution | Suitable for Indirect Immunofluorescence analysis by Flow Cytometry: 1/1000. |
Reactivity | Human, Monkey |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria |
Specificity | The antibody MEM-18 reacts with CD14, a 53-55 kDa GPI (glycosylphosphatidylinositol)-linked membrane glycoprotein expressed on monocytes, macrophages and weakly on granulocytes; also expressed by most tissue macrophages. In human, the epitope recognized by MEM-18 is located between amino acids 57-64. |
Formulation | PBS, pH~7.4 Label: Biotin State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. |
Concentration | lot specific |
Conjugation | Biotin |
Storage Condition | Store undiluted at 2-8°C. |
Gene Name | CD14 molecule |
Database Link | |
Background | CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes. |
Synonyms | CD14 |
Reference Data |
Citations (9)
The use of this Antibodies has been cited in the following citations: |
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Hepatic progenitor cells from adult human livers for cell transplantation
,Weiss TS, Lichtenauer M, Kirchner S, Stock P, Aurich H, Christ B, Brockhoff G, Kunz-Schughart LA, Jauch KW, Schlitt HJ, Thasler WE,
Gut
,PubMed ID 18417531
[CD14]
|
CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts
,Angel CE, Lala A, Chen CJ, Edgar SG, Ostrovsky LL, Dunbar PR,
Int. Immunol.
,PubMed ID 17804688
[CD14]
|
Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement
,Drbal K, Moertelmaier M, Holzhauser C, Muhammad A, Fuertbauer E, Howorka S, Hinterberger M, Stockinger H, Sch|tz GJ,
Int. Immunol.
,PubMed ID 17446208
[CD14]
|
The CD14 region spanning amino acids 57-64 is critical for interaction with the extracellular Toll-like receptor 2 domain
,Iwaki D, Nishitani C, Mitsuzawa H, Hyakushima N, Sano H, Kuroki Y,
Biochem. Biophys. Res. Commun.
,PubMed ID 15670766
[CD14]
|
Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression
,Sing A, Rost D, Tvardovskaia N, Roggenkamp A, Wiedemann A, Kirschning CJ, Aepfelbacher M, Heesemann J,
J. Exp. Med.
,PubMed ID 12391013
[CD14]
|
Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL
,Stvckl J, Majdic O, Fischer G, Maurer D, Knapp W,
J. Immunol.
,PubMed ID 11509616
[CD14]
|
CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited
,Funda DP, Tuckova L, Farri MA, Iwase T, Moro I, Tlaskalova-Hogenova H,
Infect. Immun.
,PubMed ID 11349042
[CD14]
|
Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14
,Bazil V, Baudys M, Hilgert I, Stefanova I, Low MG, Zbrozek J, Horejsm V,
Mol. Immunol.
,PubMed ID 2779588
[CD14]
|
Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen
,Bazil V, Horejsm V, Baudys M, Kristofova H, Strominger JL, Kostka W, Hilgert I,
Eur. J. Immunol.
,PubMed ID 3493149
[CD14]
|
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