CD15 Mouse Monoclonal Antibody [Clone ID: MEM-158]

Specifications

Product Data
Clone Name	MEM-158
Applications	FC
Recommend Dilution	Suitable for Flow cytometry (1/1000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human granulocytes.
Specificity	CD15 antigen (Lewisx blood group antigen). HLDA Workshop VI: WS Code A053
Formulation	PBS pH 7.4 with 15 mM sodium azide as preservative. Label: Biotin State: Liquid
Concentration	lot specific
Purification	Purified
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE!
Background	CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide (3-determinant3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin´s disease.
Synonyms	Lewis X, X-Hapten, Lacto-N-Fucopentaose III, Stage-Specific Embryonic Antigen, SSEA1
Reference Data

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