CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: MEM-154]
CAT#: SM3011F
CD16 (FCGR3A) mouse monoclonal antibody, clone MEM-154, FITC
Conjugation: Unconjugated Biotin
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CNY 3,810.00
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Specifications
Product Data | |
Clone Name | MEM-154 |
Applications | FC |
Recommend Dilution | Flow Cytometry: Analysis of Human blood cells using 20 µl reagent / 100 µl of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human granulocytes |
Specificity | The antibody reacts with the epitope on CD16 antigen that residing in proximity to FG loop (probably BC or C'E loop). CD16 is a low affinity receptor for aggregated IgG (FcgRIII antigen). The antibody MEM-154 reacts with CD16+ granulocytes. |
Formulation | PBS containing 15 mM Sodium Azide as preservative and 0.2% (w/v) high-grade Protease free BSA as a stabilizing agent. Label: FITC State: Liquid purified Ig fraction. Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated |
Conjugation | FITC |
Storage Condition | Store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Gene Name | Fc fragment of IgG receptor IIIa |
Database Link | |
Background | CD16 (FcgRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgRIII is expressed in two forms FcgRIII-A and -B. FcgRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FceRI-g subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgRIII-A is associated, moreover, with FceRI-b subunit. Besides IgG, FceRI-A can be triggered also by oligomeric IgE. FcgRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype. |
Synonyms | FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2 |
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