CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: MEM-154]
CAT#: SM3011P
CD16 (FCGR3A) mouse monoclonal antibody, clone MEM-154, Purified
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CNY 3,140.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | MEM-154 |
Applications | FC, FN, IP, WB |
Recommend Dilution | Flow Cytometry: 5-10 μg/ml. Positive control: PBL (peripheral blood lymphocytes). Immunoprecipitation. Western Blotting (Non-reducing conditions). Functional Assay (The antibody blocks binding of Human IgG to FcgammaRIII). |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human granulocytes. |
Specificity | The antibody reacts with with the epitope on CD16 antigen that residing in proximity to FG loop (probably BC or C'E loop). The antibody MEM-154 recognizes a polymorphism of CD16a (NK cells form), it reacts well with granulocyte form (CD16b) of all subjects. |
Formulation | TBS, pH~8.0 containing 15 mM Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein-A |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | Fc fragment of IgG receptor IIIa |
Database Link | |
Background | CD16 (FcgRIII) is a 50-80 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgRIII is expressed in two forms FcgRIII-A and -B. FcgRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FceRI-g subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgRIII-A is associated, moreover, with FceRI-b subunit. Besides IgG, FceRI-A can be triggered also by oligomeric IgE. FcgRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype. |
Synonyms | FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2 |
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