CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: MEM-154]

CAT#: SM3011P

CD16 (FCGR3A) mouse monoclonal antibody, clone MEM-154, Purified

Conjugation: Unconjugated Biotin FITC



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CNY 3,140.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name MEM-154
Applications FC, FN, IP, WB
Recommend Dilution Flow Cytometry: 5-10 μg/ml.
Positive control: PBL (peripheral blood lymphocytes).
Immunoprecipitation.
Western Blotting (Non-reducing conditions).
Functional Assay (The antibody blocks binding of Human IgG to FcgammaRIII).
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human granulocytes.
Specificity The antibody reacts with with the epitope on CD16 antigen that residing in proximity to FG loop (probably BC or C'E loop).
The antibody MEM-154 recognizes a polymorphism of CD16a (NK cells form), it reacts well with granulocyte form (CD16b) of all subjects.
Formulation TBS, pH~8.0 containing 15 mM Sodium Azide as preservative.
State: Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration lot specific
Purification Affinity Chromatography on Protein-A
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name Fc fragment of IgG receptor IIIa
Background CD16 (FcgRIII) is a 50-80 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgRIII is expressed in two forms FcgRIII-A and -B. FcgRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FceRI-g subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgRIII-A is associated, moreover, with FceRI-b subunit. Besides IgG, FceRI-A can be triggered also by oligomeric IgE. FcgRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
Synonyms FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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